Biochemistry
| Full details for "Cortisol". | |
|---|---|
Name |
Cortisol |
Alternative name/Profile |
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Department |
Biochemistry |
Investigation |
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Specimen type |
Serum |
Sample type |
Please comment on specimen if sample is part of a dexamethasone suppression test. |
Sample container & volume |
5 mL - Red Tube |
Frequency of analysis |
Monday - Friday during core working hours. |
Turnaround time |
1 working day |
Availability |
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Notes |
A level of <50nmol/L is based on the Endocrine Society Guidelines: Researchers have used cut-off values for the suppression of serum cortisol from 100–200 nmol/L when measured by modern RIA. A widely cited normal response is a serum cortisol less than <140nml/L. Because some patients with Cushing’s disease demonstrate suppressibility to dexamethasone, use of this diagnostic criterion misclassified up to 15% of such patients as negative. Therefore, to enhance sensitivity, experts have advocated requiring a lower cut-off for suppression of the post-dexamethasone serum cortisol to less than 50nmol/L to achieve sensitivity rates of greater than 95%. |
Related links |
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Reference range |
Morning sample ( 6 - 10 am): 166 - 507 nmol/L Afternoon sample (4 - 8 pm): 77 - 291 nmol/L |
Last updated |
Thu, 16 Apr 2020 11:56:50 IST |