Name |
Paraprotein (Serum)
|
Alternative name/Profile |
PARA, Total Protein, ELEC, Serum Protein Electrophoresis (SPEP), Multiple Myeloma (MM), Bence Jones Protein (BJP), Free light chains, FKFL, IgG, IgA, IgM, IgD, GAM, Immunoglobulins, Paraprotein, Monoclonal Gammopathy of Unknown Significance (MGUS) |
Department |
Immunology |
Investigation |
Capillary Zone Electrophoresis (CZE) (Sebia, Capillarys 3 Tera) |
Specimen type |
Clotted blood
|
Sample type |
Serum |
Sample container & volume |
5ml Red. |
Frequency of analysis |
Daily Monday to Friday |
Turnaround time |
7 days
|
Availability |
|
Notes |
Useful for:
- Monitoring monoclonal gammopathies.
Clinical Information:
- Serum proteins may be divided into six fractions using electrophoresis; the albumin, alpha-1, alpha-2, beta-1, beta-2 and gamma regions.
- The concentration of the regions and pattern of the electrophoreis can be charateristic of some disease processes. These include monoclonal gammopathies, alpha-1-antitrypsin deficiency and some inflammatory conditions.
- A monoclonal band in the gamma region, and occasionally in the alpha and beta regions, is characteristic of Multiple Myeloma or a Monoclonal Gammopathy of Unknown Significance (MGUS).
- Immunofixation is used to identify the heavy chain and/or light chain of the monoclonal protein and is requested by the laboratory.
- Quantitation of the monoclonal band is used to monitor patients. This is requested by the laboratory.
- A monoclonal band (IgG>15g/L, IgA>10g/L and IgM>10g/L) is considered consistent with a possible diagnosis of multiple myeloma.
- A monoclonal band (IgG<15g/L, IgA<10g/L and IgM<10g/L) is considered consistant with a possible diagnosis of MGUS.
Please Note:
- It is recommended that an early morning urine sample be sent for analysis on all new Multiple Myeloma patients.
- Where External Institiutions cannot guarantee immediate delivery, samples must be centrifuged, separated and stored at 4oC. Samples can then be transported, as soon as possible, to St. James's Hospital for processing.
|
Related links |
|
Reference range |
Paraprotein (PARA):
Total protein:
60-80g/L
Paraprotein:
Paraprotein level reported in g/L
Immunofixation:
Details the absence (no abnormal bands) or presence of a monoclonal protein.
Monoclonal proteins include Free kappa chains (FKC) and Free lambda chains (FLC) (Bence Jones Protein (BJP)) and IgG type Kappa (GK)/IgG type Lambda (GL)/IgA type Kappa (AK)/IgA type Lambda (AL)/IgM type Kappa (MK)/IgM type Lambda (ML). |
Last updated |
Tue, 09 Jun 2020 15:46:27 IST |
