Immunology

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Investigation

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Notes

Useful for:

• Investigating patients suspected of having Antiphospholipid Syndrome.

Clinical Information:

• Beta-2 Glycoprotein 1 is a protein produced by hepatocytes, endothelial cells and trophoblast cells.
• Beta-2 Glycoprotein 1 complexes extracellularly with phospholipids, such as cardiolipin, in vivo.
• Healthy individuals can have low levels of antibodies against these complexes of Cardiolipin and Beta-2 Glycoprotein 1.
• Higher concentrations of antibodies against these complexes of Cardiolipin and Beta-2 Glycoprotein 1 occur in patients with Antiphospholipid Syndrome.
• A diagnosis of Antiphospholipid Syndrome requires that one clinical criteria and one laboratory criteria be met.
• The clinical criteria include vascular thromboses and recurrent miscarriages.
• The laboratory criteria require the demonstration of positive lupus anticoagulant antibodies and/or cardiolipin antibodies (IgG or IgM) and/or Beta-2 Glycoprotein 1 antibdies (IgG or IgM). These positive tests must be demonstrated on at least 2 occasions, separated by a peroid of 12 weeks.

Please Note:

• The Beta-2 Glycoprotein 1 antibody assay performed in this laboratory is for the IgG antibody isotype.
• All requests for Beta-2 Glycoprotein 1 also have a Cardiolipin antibody (IgG) assay performed.
• Where External Institiutions cannot guarantee immediate delivery, samples must be centrifuged, separated and stored at 4^oC. Samples can then be transported, as soon as possible, to St. James's Hospital for processing.

Related links

Reference range

<7.0 IU/ml = Negative

7.0 - 10 IU/ml = Equivocal

>10 IU/ml = Positive

Reference Ranges provided by Phadia, May 2011.

Last updated

Tue, 09 Jun 2020 15:43:32 IST