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Immunology


Full details for "Glomerular Basement Membrane Antibodies (IgG)".  

Name

 Glomerular Basement Membrane Antibodies (IgG)

Alternative name/Profile

 GBM, Glomerulonephritis, Goodpasture Syndrome, Goodpasture's Syndrome, ANCA, Cytoplasmic Neutrophil Antibodies, Perinuclear Cytoplasmic Antibodies, pANCA, cANCA, Myeloperoxidase, MPO, Proteinase 3, PR3, Wegener's Granulomatosis, Granulomatosis with Polyangitis, GPA, Microscopic Polyangitis, MPA

Department

 Immunology

Investigation

 Immunoassay (Phadia 2500 and ImmunoCap 250)

Specimen type

 Clotted blood

Sample type

 Serum

Sample container & volume

 5ml Red.

Frequency of analysis

 Daily, Monday to Friday.

Turnaround time

 3 days

Availability

Notes

Useful for:

  • Investigating patients with renal failure or pulmonary hemorrhage associated with Goodpasture Syndrome.

Clinical Information:

  • Glomerular Basement Membrane (GBM) antibodies cause glomerulonephritis, characterised by rapid onset renal failure and/or pulmonary hemorrhage.
  • Glomerular Basement Membrane (GBM) antibodies are associated with the non-collagenous carboxyl extension of Type IV procollagen.
  • Goodpasture Syndrome usually occurs in males between the ages of 20 to 40 and over 50.
  • Glomerulonephritis without pulmonary involvement due to Glomerular Basement Membrane (GBM) antibodies is most common in women who are over 50.

Please Note:

  • This test is also available on an urgent basis by arrangement with the laboratory. For urgent tests the turnaround time is approximately three hours from specimen receipt. The cut-off time for sample receipt is 15.00 on Fridays.
  • Where External Institiutions cannot guarantee immediate delivery, samples must be centrifuged, separated and stored at 4oC. Samples can then be transported, as soon as possible, to St. James's Hospital for processing.

Related links

https://www.stjames.ie/media/Urgent%20ANCA%20GBM%20Request%20Procedure.pdf 

Reference range

<7.0 U/ml = Negative

7.0-10 U/ml = Equivocal

>10.0 U/ml = Positive

 Reference Ranges provided by Phadia 2007.

SJH Patients Only

 No

Last updated

Mon, 20 Mar 2023 12:08:31 GMT


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