Name |
Glutamic Acid Decarboxyalse (GAD) Antibody |
Alternative name/Profile |
GAD65, Beta-cell, Beta cell, Pancreatic Islet Cell, Protein Tyrosine Phosphatase (IA2), islet cells (ICA), insulin (IAA), Diabetes, Stiff-Man Syndrome, Autoimmune Neurologic Disorders |
Department |
Immunology |
Investigation |
ELISA (EUROIMMUN Anti-GAD (IgG)) |
Specimen type |
Clotted blood
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Sample type |
Serum |
Sample container & volume |
5ml Red |
Frequency of analysis |
Batch basis |
Turnaround time |
21 days |
Availability |
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Notes |
Useful for:
- Identifying patients at increased risk of developing Type-1 Autoimmune Diabetes.
- Distinguishing Type-1 Diabetes from Type-2 Diabetes.
- Confirming a diagnosis of Stiff-Man Syndrome or other related autoimmune neurologic disorders, such as autoimmune encephalitis or neuromyelitis optica.
- Identifying patients at risk of developing an organ-specific neurologic disorder, such as Myasthenia Gravis.
Clinical Information:
- Glutamic Acid Decarboxyalse (GAD) is primarily a neuronal enzyme, therfore antibodies agaist Glutamic Acid Decarboxyalse (GAD) can be found in several autoimmune neuronal disorders.
- Glutamic Acid Decarboxyalse (GAD) can also be found in the pancreatic Beta-cells. Consequently, antibodies to Glutamic Acid Decarboxyalse (GAD) can also be used as a marker of predisposition to Type-1 Autoimmune Diabetes.
Please Note:
- The ELISA specifically tests for autoantibodies directed against the GAD65 isoform of Glutamic Acid Decarboxyalse (GAD).
- It is recommended that autoantibodies directed against protein tyrosine phosphatase (IA2), islet cells (ICA) and insulin (IAA) also be tested when investigating patients for their risk of developing Type-1 Autoimmune Diabetes.
- Where External Institiutions cannot guarantee immediate delivery, samples must be centrifuged, separated and stored at 4oC. Samples can then be transported, as soon as possible, to St James's Hospital for processing.
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Related links |
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Reference range |
Negative: 0 - 10IU/ml
Reference Range provided by EUROIMMUN, Anti-Glutamic Acid Decarboxyalse (GAD) ELISA (IgG) version 12/07. |
Last updated |
Wed, 15 Mar 2023 12:03:47 GMT |