Name |
Immunoglobulin G (IgG) Subclasses |
Alternative name/Profile |
IgG1, IgG2, IgG3, IgG4, Humoral immunodeficiency, CVID, Combined Variable Immunodeficiency |
Department |
Immunology |
Investigation |
Turbidimetry (Optalite Clinical Chemistry Analyser) |
Specimen type |
Clotted blood |
Sample type |
Serum |
Sample container & volume |
5ml Red. |
Frequency of analysis |
Twice weekly |
Turnaround time |
10 days
|
Availability |
|
Notes |
Useful for:
- Investigating patients for humoral or combined immunodeficiency.
Clinical Information:
- Immunoglobulin G (IgG) represents about 80% of normal serum immunoglobulin.
- Approximately 65% of total IgG is IgG1, 25% is IgG2, 6% is IgG3 and 4% is IgG4.
- The subclass of IgG is determined by differences in the gamma heavy chain.
- IgG1 subclass deficiency usually occurs in conjunction with a deficiency in the other subclasses. This results in a severe immunoglobulin deficiency.
- IgG2 subclass deficiency can occur in isolation or in combination with:
Another IgG subclass deficiency,
Immunoglobulin A (IgA) deficiency.
- Isolated IgG3 and IgG4 deficiencies are rare.
Please Note:
- As IgG4 deficiency is rare and is best used to investigate IgG4-related disease, IgG4 levels are not included in the IgG subclass request.
- Where External Institiutions cannot guarantee immediate delivery, samples must be centrifuged, separated and stored at 4oC. Samples can then be transported, as soon as possible, to St. James's Hospital for processing.
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Related links |
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Reference range |
| Age |
IgG1 (g/L) |
IgG2 (g/L) |
IgG3 (g/L) |
| Chord blood |
3.6 - 8.4 |
1.2 - 4.0 |
0.3 - 1.5 |
| 0 - 6 Months |
1.5 - 3.0 |
0.3 - 0.5 |
0.1 - 0.6 |
| 6 Months - 2 Years |
2.3 - 5.8 |
0.3 - 2.9 |
0.1 - 0.8 |
| 2 - 5 Years |
2.3 - 6.4 |
0.7 - 4.5 |
0.1 - 1.1 |
| 5 - 10 Years |
3.6 - 7.3 |
1.4 - 4.5 |
0.3 - 1.1 |
| 10 - 15 Years |
3.8 - 7.7 |
1.3 - 4.6 |
0.2 - 1.2 |
| Adult |
3.2 - 10.2 |
1.2 - 6.6 |
0.2 - 1.9 |
IgG1, IgG2 and IgG3 ranges are sourced from Protein Reference Unit (PRU) Sheffield and last updated 14th January 2013 (http://www.immqas.org.uk/pru.asp?ID=316)
|
SJH Patients Only |
No |
Last updated |
Wed, 06 Jan 2021 16:47:45 GMT |
