Immunology

Full details for "Immunoglobulin Subclass 4 (IgG4)".

Name

Immunoglobulin Subclass 4 (IgG4)

Alternative name/Profile

Autoimmune Pancreatitis, Mikulicz disease, Sclerosing Sialadenitis, Inflammatory Orbital Pseudotumor, Chronic Sclerosing Aortitis, Reidel Thyroiditis, Hashimoto Thyroiditis, Interstitial Pneumonitis, Tubulointerstitial Nephritis.

Department

Immunology

Investigation

Turbidimetry (Optalite Clinical Chemistry Analyser )

Specimen type

Clotted blood

Sample type

Serum

Sample container & volume

Red 5ml

Frequency of analysis

Weekly

Turnaround time

7 days

Availability

Notes

Useful for:

Investigating patients for IgG4-related disease.

Clinical Information:

Immunoglobulin G (IgG) represents about 80% of normal serum immunoglobulin.
Approximately 65% of total IgG is IgG1, 25% is IgG2, 6% is IgG3 and 4% is IgG4.
The subclass of IgG is determined by differences in the gamma heavy chain.
IgG4-related disease is characterised by a tumorlike swelling in the involved organ, infiltrated with IgG4 positive plasma cells.
Conditions that may be associated with IgG4-related disease include Autoimmune Pancreatitis, Mikulicz disease, Sclerosing Sialadenitis, Inflammatory Orbital Pseudotumor, Chronic Sclerosing Aortitis, Reidel Thyroiditis, Hashimoto Thyroiditis, Interstitial Pneumonitis and Tubulointerstitial Nephritis.

Please Note:

As this test is most useful in the investigation of IgG4-related disease, IgG4 levels are not measured in combination with the other Immunoglobulin Subclasses.
Where External Institiutions cannot guarantee immediate delivery, samples must be centrifuged, separated and stored at 4^oC. Samples can then be transported, as soon as possible, to St. James's Hospital for processing.

Related links

Reference range

Age	IgG4 (g/L)
0 - 2 Years	0.005 - 0.784
2 - 4 Years	0.01 - 0.537
4 - 6 Years	0.018 - 1.125
6 - 8 Years	0.004 - 0.992
8 - 10 Years	0.019 - 0.932
10 - 12 Years	0.016 - 1.15
12 - 14 Years	0.037 - 1.36
14 - 18 Years	0.11 - 1.57
Adults	0.039 - 0.864