Name |
Paraneoplastic Antibodies |
Alternative name/Profile |
Neuronal, Hu, Type-1 Anti-Neuronal Antibody (ANNA-1), ANNA-2, Ri, Yo, Tr (DNER), Purkinje Cells, Ma, Ta, PNMA2, Amphiphysin, RMP, CV2, CRMP5, Zic4, SOX1, Titin, GAD65, Encephalomyelitis, Opsoclonus Monoclonus Ataxia (POMA), Cerebellar Degeneration (PCD), Limbic/Brain Stem Encephalomyelitis, Lambert-Eaton Myasthenic Syndrome (LEMS), Small Cell Lung Cancer (SCLC), Neuroblastoma, Fallopian/Breast/Testicular/Ovarian/Uterine Cancer, Hodgkin's Disease, Myasthenia Gravis, Stiff Person Syndrome (SPS), blot |
Department |
Immunology |
Investigation |
Indirect Immunofluorescence and Immunoblot (EUROIMMUN) |
Specimen type |
Blood |
Sample type |
Serum |
Sample container & volume |
5ml Red |
Frequency of analysis |
Batch Basis |
Turnaround time |
21 days |
Availability |
|
Notes |
Useful for:
- Investigating new onset dementia and cognitive impairment in patients suspected of having autoimmune encephalopathies due to paraneoplastic antibodies.
Clinical Information:
- Detection of neuronal autoantibodies in serum indicate an autoimmune aetiology and raise suspicions that there may be a paraneoplastic cause.
- Neurological presentations are often diverse, therefore comprehensive antibody testing is usually more informative than targeted testing for 1 or 2 antibodies.
- Some of the neuronal antibodies can be highly predictive of an underlying cancer. Please see the table below for a list of neuronal antibodies and their associated underlying caner.
| Paraneoplastic/Neuronal Antibody |
Frequenly Associated Cancer |
Clinical Presentation |
|
Hu
(Type 1 Anti-Neuronal Antibody (ANNA-1))
|
Small Cell Lung Cancer (SCLC), Neuroblastoma
|
Paraneoplastic Encephalomyelitis, Polyneuropathy |
|
Ri
(Type 2 Anti-Neuronal Antibody ANNA-2))
|
Neuroblastoma (children),
Fallopian/Breast Cancer and Small Cell Lung Cancer (SCLC) (adults)
|
Paraneoplastic Opsoclonus Monoclonus Ataxia (POMA) |
|
Yo
(Anti-Purkinje Cell Antibody (PCA-1))
|
Gynaecological Tumors, Breast Cancer |
Paraneoplastic Cerebellar Degeneration (PCD) |
|
Tr (DNER)
(Anti-Purkinje Cell Antibody)
|
Hodgkin's Lymphoma |
Paraneoplastic Cerebellar Degeneration (PCD) |
| Recoverin |
Small Cell Lung Carcinoma (SCLC) |
Retinopathy |
| Ta/Ma2/PNMA2 |
Testicular Tumors |
Limbic/Brain Stem Encephalomyelitis, Rhomboencephalitis |
| Amphiphysin |
Breast Cancer, Small Cell Lung Cancer (SCLC) |
Stiff Person Syndrome (SPS) |
| CV2/CRMP5 |
Small Cell Lung Cancer (SCLC), Thymoma |
Limbic Encephalitis |
| Zic4 |
Small Cell Lung Cancer (SCLC), Thymoma |
Cerebellar Degeneration |
| SOX1 |
Small Cell Lung Cencer (SCLC) |
Lambert-Eaton Myasthenic Syndrome (LEMS), Paraneoplastic Cerebellar Degeneration (PCD) |
| Titin |
Thymoma |
Myasthenia Gravis |
| GAD65 |
Breast/Colon Cancer, Small Cell Lung Cancer (SCLC) |
Stiff Person Syndrome (SPS) |
Please Note:
- Indirect immunofluoresence performed on all requests for Paraneoplastic antibodies. Immunoblot will be carried out as a follow on confirmatory test when a pattern is detected.
- Immunofluorescence screen does not include anti-Recoverin, anti SOX-1 (AGNA) and anti-Titin antibodies. In high clinical suspicion please contact the Immunology laboratory to request an Immunoblot.
- Where External Institiutions cannot guarantee immediate delivery, samples must be centrifuged, separated and stored at 4oC. Samples can then be transported, as soon as possible, to St. James's Hospital for processing.
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Related links |
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Reference range |
Indirect Immunofluorescence: Negative or For Further investigation.
Immunoblot: Negative, Weak positive, Positive and Strong positive.
|
Last updated |
Fri, 19 Jul 2024 09:36:56 IST |
