Name |
Interleukin 6 (IL-6) |
Alternative name/Profile |
IL6, IL-6, Arthritis, Inflammatory Bowel Disease (IBD), Crohn's Disease, Sepsis, Septicaemia, Rheumatoid Arthritis, Systemic Lupus Erythematosis (SLE) or Alkyloising Spondilitis |
Department |
Immunology |
Investigation |
ELISA (R&D Systems, Quantikine ELISA, Human IL-6) |
Specimen type |
Clotted blood |
Sample type |
Serum |
Sample container & volume |
5ml Red. |
Frequency of analysis |
Batch basis |
Turnaround time |
21 days |
Availability |
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Notes |
Useful for:
- Evaluating patients with systemic infection.
- Evaluating patients with suspected localised infection (prosthetic joint infection (PJI)).
- Evaluating patients with chronic inflammatory conditions such as Rheumatoid Arthritis, Inflammatory Bowel Disease (IBD), Systemic Lupus
- Erythematosis (SLE) or Alkyloising Spondilitis.
Clinical Information:
- Interleukin 6 (IL-6) plays a role in both the innate and adapative immune responses.
- IL-6 drives the acute inflammatory response associated with innate immunity. This results in fever and the induction of expression of C-reactive Protein (CRP), Serum Amyloid A (SAA) and fibrinogen in the liver.
- As part of the adaptive immune response IL-6 is involved in activating the proliferation and diffrentiation of antibody producing B-cells.
- Dyregulation of IL-6 can contribute to chronic inflammatory disease. In particular, as IL-6 is involoved in bone resorption, it plays a mojor role in inflammatory joint destruction in Rheumatoid Arthritis.
Please Note:
- Samples for IL-6 must be received in the laboratory as soon as possible post collection.
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Related links |
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Reference range |
0.00 - 7.26 pg/ml
This reference range was established inhouse using the maximum and minimum values +/- 2 SD from 30 healthy adult controls in the Immunology Department, St. James's Hospital. |
SJH Patients Only |
No |
Last updated |
Wed, 15 Mar 2023 12:04:28 GMT |
