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Immunology


Full details for "CD25 (Interleukin 2 Receptor alpha)".  

Name

 CD25 (Interleukin 2 Receptor alpha)

Alternative name/Profile

 IL2, IL-2, Hemophagocytic Lymphohistiocytosis (HLH)

Department

 Immunology

Investigation

 ELISA (R&D Systems, Quantikine ELISA, Human CD25/IL-2 Rα Immunoassay)

Specimen type

 Clotted blood

Sample type

 Serum

Sample container & volume

 5ml Red.

Frequency of analysis

 Batch basis

Turnaround time

 21 Days

Availability

Notes

Useful for:

  • Evaluating patients with Hemophagocytic Lymphohistiocytosis (HLH).

Clinical Information:

  • Hemophagocytic Lymphohistiocytosis (HLH) is a severe inflammatory disorder in which there is abnormal cytotoxic T and Natural Killer cell function and excessive cytokine production. This results in continued activation of the immune system and impaired pathogen clearance.
  • Hemophagocytic Lymphohistiocytosis (HLH) can be characterised by using 6 clinical parameters; fever, splenomegaly, cytopenias, hyperferritinemia, hypertriglyceridemia/hypofibrinogenemia, and hemophagocytosis, as well as 3 laboratory tests (genetic testing, NK cell function, and serum soluble interleukin-2).
  • CD25 (Interleukin 2 Receptor alpha) levels are usually elevated in Hemophagocytic Lymphohistiocytosis (HLH).

Please Note:

  • Samples for CD25 (Interleukin 2 Receptor alpha) must be received in the laboratory as soon as possible post collection.

Related links

Reference range

101.8 - 2509.4 pg/ml

This reference range was established inhouse using the maximum and minimum values +/- 2 SD from 30 healthy adult controls in the Immunology Department, St. James's Hospital.

Last updated

Wed, 09 Mar 2022 09:26:31 GMT


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