Full details for "Anti-streptolysin O titre". | |
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Name |
Anti-streptolysin O titre |
Alternative name/Profile |
ASOT / glomerulonephritis / rheumatic fever / bacterial endocarditis / scarlet fever |
Department |
Microbiology |
Investigation |
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Specimen type |
Peripheral blood |
Sample type |
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Sample container & volume |
6 ml clotted Red top serum tube |
Frequency of analysis |
Twice weekly |
Turnaround time |
3 days |
Availability |
Tuesday & Friday |
Notes |
Detection of Anti - Streptolysin O ( ASO) in human serum may aid in the diagnosis of streptoccal infections. In these infections promoted by acute streptococcal infections, anti streptolysin O antibodies are produced due to the presence of the streptolysin O antigen liberated by the bacteria. Information on the extent and degree of infection can be obtained from the measurement of serum ASO levels. Increased ASO levels are also associated with rheumatic fever and glomerulonephritis The Rheumajet ASO kit which is employed in this laboratory uses a latex slide agglutination test for both qualitative and semi-quantitative determination of anti-Streptolysin O in serum. Contaminated, lipemic, or haemolysed sera are unsuitable as are plasma samples (fibrinogen may cause non-specific agglutination). Send sample to the laboratory without delay. Sample should be refrigerated if not transported immediately.
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Related links |
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Reference range |
Low levels of antibody tend to persist in the serum of healthy individuals and the generally accepted upper limit of normal is 200 IU/ml. However, ASO levels rise rapidly following reinfection and the demonstration of rapidly increasing antibody titres is of diagnostic significance. 200 IU/ml is regarded internationally as the upper limit of the normal range but values may vary with age, sex and geographical location.Elevated levels of ASO titres have also been found in healthy carriers. |
Last updated |
Fri, 07 Jul 2023 13:52:33 IST |