Haematology
| Full details for "Paroxysmal Nocturnal Haemoglobinuria (PNH) Screen". | |
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Name |
Paroxysmal Nocturnal Haemoglobinuria (PNH) Screen |
Alternative name/Profile |
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Department |
Haematology |
Investigation |
Flow cytometry is considered the gold standard for PNH diagnosis & monitoring. It is performed by demonstrating the absence of Glycosyl Phosphatidyl anchor proteins in peripheral blood RBCs, neutrophils & monocytes which are caused by the PNH PIG-A mutation. This is done though both indirect (absence of antigen that should have been bound to the protein) and direct (absence of protein) methods. |
Specimen type |
Peripheral Blood (must be tested within 48hrs of venepuncture) |
Sample type |
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Sample container & volume |
1 x 4ml EDTA Purple |
Frequency of analysis |
As Required |
Turnaround time |
7 working days |
Availability |
Routine hours 9am to 5pm Monday to Friday Please send samples for PNH analysis Monday to Thursday only. Analysis must be performed within 48 hours of venipuncture. |
Notes |
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Related links |
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Reference range |
PNH results are reported as positive or negative. Where a positive clone has been reported, the clone size will be reported as %PNH for CD59 (RBC), CD24 and Flaer (Neutrophils) and CD14 (Monocytes) |
Last updated |
Wed, 14 Jan 2026 15:57:43 GMT |